How are DLS and ELS used to measure particle size and zeta potential?ĭynamic Light Scattering (DLS) measures the diffusion rate of suspended particles or molecules in solution and if we know the dispersant or solvent viscosity, we can calculate the mean particle size, polydispersity and, with enhanced algorithms, produce a particle size distribution.DLS has become a very useful tool in nanoparticle research and production as well as in the life sciences.DLS is quick, non-destructive and is sensitive to the presence of such things as agglomerates – it’s therefore a great tool for checking, is my sample in the form I want it to be in?Įlectrophoretic light scattering (ELS) measures the mobility of a particulate suspension in the presence of an applied electrical field.The mobility rate and the strength of the electrical field are used to determine the charge or zeta potential of the particles – this is useful in predicting their behaviour or the likely stability of a formulation – are my particles likely to aggregate or behave as a stable suspension? Are my particles likely to interact with their target or environment, for instance? What challenges do researchers face when analyzing particle concentration? An interview with Darrell Bancarz, highlighting Multi-Angle Dynamic Light Scattering as a new approach to overcome challenges in particle sizing.
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